PD01-07 MEDICAL-GRADE MANUKA HONEY (MEDIHONEY®) POTENTIAL EFFICACY IN THE MANAGEMENT OF INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME: AN IN VITRO MODEL OF UROTHELIAL INFLAMMATION

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease the Genitourinary Tract: Interstitial Cystitis (PD01)1 Sep 2021PD01-07 MEDICAL-GRADE MANUKA HONEY (MEDIHONEY®) POTENTIAL EFFICACY IN THE MANAGEMENT OF INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME: AN VITRO MODEL UROTHELIAL INFLAMMATION Muhammadbakhoree Yusuh, Laurie Lau, Omar Abdelwahab, Kamaluddeen Garba, Prapussara Sirikhansaeng, Brian Birch, and Bashir Lwaleed YusuhMuhammadbakhoree Yusuh More articles by this author , LauLaurie Lau AbdelwahabOmar Abdelwahab GarbaKamaluddeen Garba SirikhansaengPrapussara Sirikhansaeng BirchBrian Birch LwaleedBashir View All Author Informationhttps://doi.org/10.1097/JU.0000000000001965.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Cystitis/Bladder Pain Syndrome (IC/BPS) refers “spontaneous” conditions varied aetiologies defined as chronic pelvic pain, pressure or discomfort, urge void, frequency nocturia. It is characterised bladder wall inflammation, defective urothelium, increased levels pro-inflammatory cytokine TNF-α in tissue. The release urothelial cells further aggravates inflammatory response patients with IC/BPS. Commonly, Medical grade Manuka honey (Medihoney® (MH)) possesses strong pro-angiogenic anti-microbial properties. Our recent findings highlighted its anti-inflammatory effects through inhibition induced mast cell degranulation. In addition, we demonstrated that MH well tolerated rat where it was cytoprotective against acid damage. present study, investigated cytotoxic using an vitro model primary human (HUCs). METHODS: Cytotoxic effect various concentrations on HUCs at 1, 24, 48, 72 hours evaluated MTT assay. cytokines IL-8 IL-6 after 24-hour incubation (10 ng/ml) with/without pre-treatment 4% assessed ELISA assays. RESULTS: One hour (2%, 4%, 6% 8% w/v) did not induce significant HUCs. However, when were incubated for a longer periods, observed incremental effect, especially (Figure 1). significantly decreased 2). CONCLUSIONS: results indicate has potential use intravesical therapeutic agent management such Source Funding: N/A © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e33-e33 Advertisement Copyright & Permissions© Inc.MetricsAuthor Information Expand Loading ...